تاریخ انتشار : پنجشنبه 25 آذر 1400 - 18:47
202 بازدید
کد خبر : 171423

اثر ضداضطراب اسانس “اسطوخودوس”

اثر ضداضطراب اسانس “اسطوخودوس”

اضطراب یکی از اختلالات شایع مربوط به اعصاب و روان است که می تواند به قدری شدید باشد که فعالیت های روزانه فرد را مختل کند. به گزارش ایسنا، به نقل از پژوهشکده گیاهان دارویی جهاد دانشگاهی، سازمان جهانی بهداشت اعلام کرده که ۶/۳ درصد جمعیت جهان در سال ۲۰۱۵  دچار اضطراب بوده اند؛ البته، این

اثر ضداضطراب اسانس "اسطوخودوس"

اضطراب یکی از اختلالات شایع مربوط به اعصاب و روان است که می تواند به قدری شدید باشد که فعالیت های روزانه فرد را مختل کند.

به گزارش ایسنا، به نقل از پژوهشکده گیاهان دارویی جهاد دانشگاهی، سازمان جهانی بهداشت اعلام کرده که ۶/۳ درصد جمعیت جهان در سال ۲۰۱۵  دچار اضطراب بوده اند؛ البته، این عدد در کشورهای مختلف، متفاوت است.

برای درمان اضطراب معمولا” از گروهی از داروها به نام بنزودیازپین ها مانند lorazepam، oxazepam، chlordiazepoxide و diazepam استفاده می شود.

یکی از معایب بنزودیازپین ها این است که باعث کاهش فعالیت حرکتی بیمار می‌شوند.

یک پژوهش اخیر در موش سوری (mice) نشان داده که ماده ای به نام linalool در اسانس اسطوخودوس (Lavandula officinalis) (lavender)  باعث می شود که استنشاق بوی این اسانس با تحریک عصب بویایی اثر ضداضطراب شبیه بنزودیازپین ها بدون کاهش فعالیت حرکتی ایجاد کند. همچنین، طرز کار ماده مذکور در ایجاد اثر ضداضطراب با بنزودیازپین فرق داشته است.

انتهای پیام

ارسال نظر شما
مجموع نظرات : 0 در انتظار بررسی : 0 انتشار یافته : ۰
  • نظرات ارسال شده توسط شما، پس از تایید توسط مدیران سایت منتشر خواهد شد.
  • نظراتی که حاوی تهمت یا افترا باشد منتشر نخواهد شد.
  • نظراتی که به غیر از زبان فارسی یا غیر مرتبط با خبر باشد منتشر نخواهد شد.

htthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtthtt